Journal of AdvancedMedical and Dental Sciences Research

Background: Oral submucous fibrosis is chronic progressive diseases of the oral cavity with potential of malignant transformation. For the treatment of this pathologic condition, a wide range of modalities consisting of drug management, surgical therapy, and physiotherapy have been attempted till date; with varying degrees of benefit, but none of them have proved to be a cure for this disease. Hence; we planned this study to compare the effectiveness of levamisole and ANTOXID (ATD) in the treatment of oral submucous fibrosis. Materials & Methods: The present study included comparative assessment of OSMF patients who underwent treatment by LVM and ATD.  All the patients were divided randomly into two study groups. Group A included patients who were given LVM thrice daily and group B included patients who were given ATD twice daily. Records of all the readings and values of the patients before starting of the treatment and during the follow-up time were maintained. All the results were analyzed by SPSS software. Results: The initial mouth opening among group A and group B patients was found to be 2.9 and 3.1 cm respectively. The mouth opening during the first follow-up period at the end of first month of treatment among group A and Group B patients was 3.2 and 3.3 cm respectively. Significant results were obtained while comparing the mean mouth opening in both the groups at different interval of time. Conclusion: Significant reduction in the mouth opening of the patients occurs with both LVM and ATD.
Key words: Antoxid, levamisole, submucous fibrosis

Corresponding author: Dr. Inderpreet Singh Oberoi, PG scholar, Department of Oral Medicine and Radiology, Government Dental College and Hospital, Srinagar,

This article may be cited as: Chalkoo AH, Oberoi IS, Dhingra K. Assessment of various treatment modalities for the treatment of oral submucous fibrosis: A comparative study. J Adv Med Dent Scie Res 2017;5(1):120-122.