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Volume 4 Issue 6 (November - December, 2016)

Original Articles

A DESCRIPTIVE STUDY OF HISTOPATHOLOGIC DIAGNOSIS OF LYMPH NODE BIOPSIES
Rekha Rani, Charu Chandra

Background: Lymphadenopathy is a common clinical problem and biopsies are usually undertaken to determine the cause of nodal enlargement, which may be neoplastic or non-neoplastic. The present study was conducted to evaluate the spectrum of histopathological diagnosis of peripheral lymph node biopsies. Materials & Methods: This study was conducted in the department of general pathology in year 2013. Sections from formalin fixed, paraffin embedded blocks and stained with H and E, stains were studied in all cases. Results: Out of 850 biopsies, 450 were of males and 400 were of females. The difference was non - significant (P > 0.05). Age group 11-20 years had 50%, 21-30 years had 12%, 31-40 years had 27%, 41-50 years had 7% and > 50 years had 4% of lesions. The difference was significant (P - 0.02). Different lesions on lymph node biopsy were Non Hodgkin lymphoma (35%), Hodgkin lymphoma (12%), Tuberculosis (22%), Follicular hyperplasia (10%), Sinus histiocytosis (6%), Paracortical hyperplasia (5%) and metastatic lesion (10%). The difference was statistical significant (P - 0.05). Among 102 hodgkin lymphoma patients, the most common type was nodular sclerosis (39) followed by mixed cellularity (32), lymphocytic rich (10), lymphocytic depleted (9), not otherwise specified (6) and nodular lymphocyte predominant (4). The difference was statistical significant (P - 0.05). Among types of non Hodgkin lymphoma, we reported T-cell/ histiocyte rich large B cell lymphoma (TCHRBL) (3%), Follicular lymphoma (7%), burkitt’s lymphoma (4%), diffuse large B- cell lymphoma (30%), lymphoplasmacytic lymphoma (8%), marginal zone lymphoma (9%), Mantle cell lymphoma (8%), angioimmunoblastic T-cell lymphoma (17%), Peripheral T- cell lymphoma (14%). Conclusion: For establishing the cause of lymphadenopathy, lymph node biopsy plays an important role. Maximum cases were of non hodgkin’s lymphoma. Younger age group was commonly encountered. Among HL, nodular sclerosis was the commonest involved type.
Key words: Hodgkin lymphoma, Lymphadenopathy, neoplastic

Corresponding Author: Dr. Rekha Rani, Assistant Professor, Department of Pathology, Career Institute of Medical Science and Hospital, Lucknow, Uttar Pradesh, India

This article may be cited as: Rani R, Chandra C. A descriptive study of histopathologic diagnosis of lymph node biopsies. J Adv Med Dent Scie Res 2016;4(6):276-279.

 
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