Journal of AdvancedMedical and Dental Sciences Research

Background: Dry eye diseases are the common ocular pathologies encountered among the general population. Lubricating the ocular surfaces with artificial tears forms the traditional therapies for dry eyes. Cyclosporine has been shown to block T-cell proliferation and receptor signal transduction. Hence; we compared the efficacy of cyclosporine 0.05% ophthalmic emulsion, as compared with vehicle in Indian population with dry eye diseases.  Materials & methods: The present study was conducted in the Department Of Ophthalmology, Shadan Institute of Medical Sciences and included assessment of 300 patients with dry eye diseases. All the patients were broadly divided into two study groups. Group 1 included patients who received cyclosporine 0.05% (1 drop, twice daily) while group 2 included patients who were administered with vehicle (1 drop, twice daily). During the first 6 months extension, patients were provided with artificial tears to be used as needed, except not within 30 minutes of cyclosporine 0.1% instillation. Within 90 days of completing the previous treatment period, patients were required to enter the second and third 6-month extensions within 90 days of completing the previous treatment period. Ocular signs and symptoms were measured at all visits, except for visual acuity, which was not evaluated at week 4.evaluation of all the patients were done at various time intervals. All the results were analyzed by SPSS software. Results: Number of patients included in both the groups was 180. Mean age of the patients in group 1 and group 2 were 48.2 and 49.1 respectively. No significant results were obtained while comparing the demographic details in between the various study groups. Mean change observed in group 1 patients and in group 2 patients at 14 days time was 2.99 and 2.65 respectively. However, significant results were obtained while comparing the p-value for the mean change in of the total score in between the two study groups. Conclusion: Cyclosporine 0.05% treatment protocol twice daily in patients with dry eyes pathologies was equally effective in comparison with the vehicle.
Key words: Cyclosporine, Dry eyes, vehicle

Corresponding author: Dr. Irfan Ahmed Khan, Final year PG, Shadan Institute of Medical Sciences, Hyderabad, Telengana

This article may be cited as: Khan IA, Qamruddin M. Evaluation of efficacy of cyclosporine ophthalmic emulsion versus vehicle in patients with dry eye diseases in Indian population: A comparative study. J Adv Med Dent Scie Res 2016;4(6):199-203.