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Volume 4 Issue 5 (September - October, 2016)

Original Articles

eEVALUATION OF CORRELATION OF TUMOR MARKERS WITH TUMOR GRADING IN BREAST CARCINOMA PATIENTS
Manjot Kaur, Kiranjot Kaur, Mridu Manjari, Vikrant Rai, Mohit Madhukar

Introduction: Histopathology is the main diagnostic procedure to determine the malignancy. Breast cancer once diagnosed, is then subjected to IHC studies. The present study was planned to find correlation of ER, PR and p53 in breast carcinoma among Indian population. Material and Methods: The present study was conducted among 50 cases of breast cancer. Haematoxylin and Eosin stained sections were used for histopathological typing and grading. All the cases were subjected to immunohistochemistry for ER, PR and p53 expression. Data so obtained was analyzed using the SPSS Version 17 software and was arranged according to characteristics and represented as a number and percentage. Results: ER positivity decreased as the grade of the tumor increased. PR positivity decreased as the grade of the tumor increased. p53 value was directly related to the grade of the tumor although not statistically significant. As the grade of the tumor increased p53 positivity was increased and ER PR positivity decreased suggesting further that ER and PR are inversely related to P53 status. Conclusion: The present study observed that ER PR positivity was present in low grade tumors and p53 positivity was more seen in high grade tumors. Thus, inverse relationship was found between ER PR positivity p53 with grade of tumor and emphasizes the need to find out the prognosis, survival and line of treatment.
Keywords: Breast Carcinoma; Estrogen receptors; Progesterone receptors;  p53; Women

Corresponding Author: Dr. Manjot Kaur, Consultant, Department of General Pathology, Ivy Hospital, Nawashahr Punjab.

This article may be cited as:Kaur M, Kaur K, Manjari M, Rai V, Madhukar M. Evaluation of correlation of tumor markers with tumor grading in breast carcinoma patients. J Adv Med Dent Scie Res 2016;4(5):131-136.

 
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