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Volume 4 Issue 4 (July - August, 2016)

Review Articles

SYNDECAN IN HEALTH AND DISEASE – A SYSTEMATIC REVIEW
Tanoj Kumar, Veena Bhojaraj Pujari, Manish Kumar, Smitha C N, Virsen Jaysingrao Patil, Satvik Kulkarni, Silvie Singh

Syndecans are heparin sulfate protoglycans that are associated with cell surface and extra cellular matrix. Invertebrates have one syndecan core protein but in mammals there are four syndecan proteins. Each protein has three major domains; ectodomain, transmembrane domain and cytoplasmic domain. Cytoplasmic domain are the most conserved and serve to regulate the signalling of growth factors. They have also been shown to be  involved in cell signalling through interaction with integrins and tyrosine kinase receptors. These cell surface proteins are thought to play an important role in cell matrix and cell - cell adhesion, migration and proliferation. So, this review summarized the structure, properties and functions of various syndecan molecules in both health and disease.
Key words: Heparin sulphate, proteoglycan, ectodomain, cell signalling, integrins

Corresponding author: Tanoj Kumar, Professor and Head, Department of Oral Pathology, Patna Dental College and Hospital, Patna, Bihar,  India

This article may be cited as: Kumar T, Pujari VB, Kumar M, C N Smitha, Patil VJ, Kulkarni S, Singh S. Syndecan in health and disease – A systematic review. J Adv Med Dent Scie Res 2016;4(4):184-189.

 
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