Journal of AdvancedMedical and Dental Sciences Research

Background: Acute pancreatitis is an acute inflammatory disease of the Pancreas which is usually self-limited within few days but may turn out into severe and destructive, causing massive destruction followed by death. Several chronic diseases are associated with increased risk of development of acute pancreatitis. Whether Diabetes is associated with the risk of acute pancreatitis is unknown. Hence we assessed the risk of development of acute pancreatitis in type II diabetic patients. Materials and Methods: We conducted a population-based case control study in a cohort of 8000 type 2 diabetic patients and 2000 diabetes-free individuals from the general population as controls using data from community health care centres database. Follow-up of the subjects was done to ascertain incident cases of acute pancreatitis. Results: 55 cases of acute pancreatitis were identified 30 in the general population and 25 in the diabetes cohort. 30.9 And 53.9 per 100,000 person-years were the incident rate seen in the general population and the diabetes cohort, respectively. When compared with diabetes free individuals, patients with type 2 diabetes had a non significantly increased risk of acute pancreatitis. The risk of acute pancreatitis was observed to decrease among insulin treated diabetic patients. Conclusion: There might be slightly higher risk of acute pancreatitis associated with Type 2 diabetes. Insulin use in type 2 diabetes might also be associated with decreased risk. Key Words: Acute pancreatitis, Diabetes, Risk

Corresponding author: Dr Shawana Barkat, Senior Resident, Department of Pharmacology, Government Medical College and Hospital, Betiah, Bihar