Journal of AdvancedMedical and Dental Sciences Research

Angiogenesis, the growth of new blood vessels from pre-existing ones, is one of hallmark of tumor formation and is also important in a number of normal physiologic processes including growth and development, wound healing.  Folkman and colleagues demonstrated that solid tumors cannot grow any larger than 2-3 mm in diameter without being able to induce their own blood supply.Tumor growth can be stunted via a number of anti- angiogenic agents which are under clinical trial, VEGF inhibitors being the most important one. But ongoing researches have shown that monotherapy with VEGF was not as effective as needed with various other side effects. Therefore there is an arising need for discovering alternative strategies to target angiogenesis in tumors.Various biomarkes for angiogenesis has been tried over the years, in both potentially malignant lesions as well as head and neck squamous cell carcinoma and their co-relation with lymph lode metastasis, grading, site, size, association with inflammation, TNM staging, bone invasion, perineural invasion has been studied by various authors.A thorough understanding of angiogenesis and its role in cancer prevention is needed to increase the overall survival rate and prognosis of cancer. 
Key Words: Angiogenesis, potentially malignant lesions, oral squamous cell carcinoma, tumor markers.

Corresponding author: Dr. Isha Makkar, Pacific dental college and hospital , Udaipur, Email: ishajuneja@yahoo.com

This article may be cited as:  Makkar I, Metgud R, Vyas Z, Tak A. Markers of angiogensis in potentially malignant lesions and oral squamous cell carcinoma. J Adv Med Dent Scie Res 2016;4(2):25-34.