Journal of AdvancedMedical and Dental Sciences Research

Central giant cell granuloma (CGCG) was first described by Jaffe in 1953, as an idiopathic non-neoplastic proliferative lesion. It accounts for about 10% of all benign lesions of the jawbones. Much controversy surrounds the nature of CGCG. Initially, it was not distinguished from giant cell tumor of the extragnathic skeleton, but later it was described by Jaffe as giant cell reparative granuloma. The clinical behavior of the lesion varies from an asymptomatic osteolytic lesion that grows slowly without expansion, to an aggressive, painful process accompanied by root resorption, cortical bone destruction, and extension into the soft tissues. Histologically and radiographically CGCG resembles giant cell tumor, giant cell lesion of hyperparathyroidism, cherubism, and aneurysmal bone cyst. Here we present a case report highlighting the clinical, radiological and histological features of central giant cell granuloma, laying emphasis on differentiating it from other similar multilocular radiolucencies. Key words: Central giant cell granuloma, aggressive, non-aggressive. Corresponding author: Navjoat Kaur, BDS (Intern), Sri Guru Ram Das Institute of Dental Sciences,Amritsar, Punjab, India, Email: navjoat.jossan23@gmail.com This article may be cited as: Kaur N, Kohli T, Chhina AK. Central giant cell granuloma: A diagnostic predicament. J Adv Med Dent Scie Res 2015;4(1):90-95.