Journal of AdvancedMedical and Dental Sciences Research

Introduction: Autoimmune blistering diseases are a rare group of mucocutaneous disorders that can result in irreversible sequelae and death if accurate diagnosis and treatment are not rendered promptly.1, 2 Two of the most common diseases in this group are pemphigus vulgaris and bullous pemphigoid, which are disorders characterized by the production of autoantibodies that target structural proteins important to the maintenance of intercellular and cell-to-basement membrane adhesion. Material & Methods: Sixty patients with pemphigus (40 with PV and 20 with PF, who were diagnosed based on clinical examination, histopathology and direct immunofluorescence) and three patients with extensive burns which were considered as controls were studied. Results: For Dsg1 ELISA, the mean was 0.143 and for Dsg3 it was 0.102. This resulted in a cut off value of 0.406 for Dsg1 ELISA and 0.212 for Dsg3 ELISA. Dsg1 and Dsg3 antibodies were found to be present in all the patients of PV and PF. Conclusion: A detailed prospective study for evaluating the ELISA levels of a given patient for prolonged periods would be helpful in actual correlation with the disease severity and changes that may occur in the spectrum of the disease.
Keywords: Pemphigus, DSG1, DSG3, ELISA

Corresponding author: Dr. Devendra Parmar, Associate Professor, Department of Skin, Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat      

This article may be cited as:  Parmar D, Shah J.  Evaluation of Dsg1 And Dsg3 molecules in Pemphigus Cases. J Adv Med Dent Scie Res 2015;3(5):S28-S31.