Journal of AdvancedMedical and Dental Sciences Research

Background: Gallstones are the most common risk factor for gallbladder cancer. Gallstones are pebble-like collections of cholesterol and other substances that form in the gallbladder and can cause chronic inflammation. The present study was conducted to assess level of CA19-9 and CA 125 in carcinoma gall bladder. Materials & Methods: 68 cases of carcinoma gall bladder of both genders were assessed for CA19-9 and CA 125 by chemiluminescent microparticle immunoassay (CMIA) method. Results: lesions found to be chronic cholecystitis in 36, xanthogranulomatous cholecystitis in 20 and chronic cholecystitis with gastric metaplasia in 12. The mean CA19-9 level was 136 U/ml and CA 125 level was 65. 2 U/ml. Conclusion: Authors found elevated level of CA19-9 and CA 125 in carcinoma gall bladder. Key words: Carcinoma gall bladder, CA19-9, CA 125