Journal of AdvancedMedical and Dental Sciences Research

Background: Dexmedetomidine is an α2 receptor agonist and its α2/α1 selectivity is 8 times higher than that of clonidine. In animal models, intrathecal dexmedetomidine has been demonstrated to have an analgesic effect. Levobupivacaine is a long-acting local anaesthetic with a pharmacological structure similar to that of bupivacaine. Aim of the study: To compare isobaric levobupivacaine versus isobaric levobupivacaine with dexmeditomidine in spinal anaesthesia. Materials and methods: The present study was conducted in the Department of Anesthesiology of the medical institution. For the study, we selected a total of 80 patients in the age group of 20-65 years of physical status American Society of Anesthesiologists (ASA) Classes I and II admitted for surgeries requiring spinal anesthesia. Group 1 and Group 2. Group 1 patients received 3 ml (15 mg) of 0.5% isobaric levobupivacaine + 0.3 ml normal saline, whereas Group 2 patients received 3 ml (15 mg) of 0.5% isobaric levobupivacaine + 0.3 ml (3 μg) dexmedetomidine. Results: In the present study, a total of 80 patients were recruited. Patients were grouped into Group 1 and 2 with 40 patients in each group. It was observed that the number of male patients in group 1 and 2 were 22 and 24, respectively. The number of female patients in group 1 and 2 was 18 and 16, respectively. The mean age of patients in group 1 was 41.25 years and in group 2 was 43.66 years. It was observed that the mean duration of sensory block in Group 2 was significantly higher than Group 1. The mean duration of motor block in both the groups was similar and was statistically non-significant. Conclusion: Addition of Dexmedetomidine with Levobupivacaine significantly increases the sensory block time. However, there is non-significant effect for motor block. Keywords: Levobupivacaine, spinal anesthesia, Dexmedetomidine.