Journal of AdvancedMedical and Dental Sciences Research

Background: Oral Submucous Fibrosis (OSF) is a chronic condition almost exclusively occurring among Indians and to a lesser extent in the other Asiatic people. The present study was conducted to compare effectiveness of oral colchicine with intralesional injection of hyaluronidase or injection triamcinolone acetonide in patients with OSMF. Materials & Methods: 36 clinically and histologically confirmed cases of OSMF were divided into 2 groups of 18 each. Group I were treated with tablet colchicine 0.5 mg twice daily with an intralesional injection of hyaluronidase 1500 IU with 0.5 ml of lignocaine hydrochloride at weekly interval for 12 weeks. Group II patients were treated by administering tablet colchicine 0.5 mg twice daily with an intralesional injection of triamcinolone acetonide 10 mg/ml at weekly interval for 12 weeks. Outcome assessment was done pre- operatively and post- operatively. Results: Group I had 12 males and 6 females and group II had 11 males and 7 females. Pre- op and post- op blanching was seen in 18 and 12 and 18 and 14 in group I and group II respectively. Burning sensation was seen in 17 and 10 in group I and 16 and 12 group II pre- op and post- op respectively. Ulceration was present in 15 and 8 in group I and 17 and 10 in group II pre- op and post- op respectively. Limited mouth opening was seen in 17 and 9 and 18 and 11 in group I and II pre- op and post- op respectively. The difference was significant (P< 0.05). Conclusion: Both combination of drugs was effective in management of OSMF cases. Colchicine in addition with hyaluronidase resulted in superior results. Key words: Colchicine, Hyaluronidase, OSMF.