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Volume 8 Issue 12 (December, 2020)

Original Articles

Assessment of plasma levels of S100A8, S100A9, and S100A12 in patients with Chronic Spontaneous Uritcaria
Kanchan Srivastava, Deepika Agarwal, Himali Tandon

Background: Chronic spontaneous uritcaria (CSU) is characterized by the spontaneous appearance of transient itchy wheals, angioedema or both, for at least 6 weeks. The present study was conducted to assess plasma levels of S100A8, S100A9, and S100A12 in patients with chronic spontaneous uritcaria. Materials & Methods: 56 patients with CSU were enrolled. Plasma levels of S100A8, S100A9, and S100A12 were assessed using enzyme linked immunosorbent assay (ELISA) kit. Results: The mean S100A8 level in group I was 1215.6 pg/ml and in group II was 2104.6 pg/ml, S100A9 level was 406.2 pg/ml in group I and 815.2 pg/ml in group II, S100A12 level was 1924.6 pg/ml in group I and 2146.8 pg/ml in group II. The difference was significant (P< 0.05). Conclusion: Plasma level of S100A8, S100A9, and S100A12 were elevated in CSU patients than those of healthy controls. Key words: Chronic spontaneous uritcaria , Plasma, angioedema

 
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