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Volume 2 Issue 3 (July-September, 2014)

Original Articles

Assessment of effectiveness of tranexamic acid (TA) in lower-limb arthroplasty- A clinical study
Keshav Gupta

Background: The present study was conducted to assess effectiveness of tranexamic acid (TA) in lower-limb arthroplasty. Materials & Methods: 138 patients selected for lower-limb arthroplasty were divided into 3 groups. Group I received no TA, group II received 15 mg/kg IV TA and group III received 3 g IA TA. The effect on calculated total blood loss, hemoglobin, transfusion, and duration of hospitalization was studied. Results: The mean age was 65.2 years in group I, 64.7 years in group II and 62.3 years in group III. Knee arthroplasty was done in 22, 20 and 24 in group I, II and III respectively. Hip arthroplasty was done in 16, 19 and 12 in group I, II and III respectively and Acetabular revision in 8, 7 and 10 in group I, II and III respectively. The mean blood loss was 542.6 ml, 328.5 ml, group III was 368.2 ml in group I, II and III respectively. Post- operative hemoglobin was 11.4 g/dl, 11.6 g/dl and 11.8 g/dl in group I, II and III respectively. The mean length of hospital stay was 7.2 days, 4.6 days and 4.4 days in group I, II and III respectively. There were 25 number in group I, 12 in group II and 8 in group III needed in group I, II and III respectively. Conclusion: Tranexamic acid administration in patients requiring lower limb surgery is an effective way of treatment. Key words: Tranexamic acid, Blood loss, lower limb surgery

 
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