Background: Oxidative stress had an important role in the pathophysiology of preeclampsia The present study was conducted to assess oxidative stress in pregnant women.
Materials & Methods: 40 pre- eclampsia pregnant cases and 40 healthy pregnant cases were enrolled. Plasma was separated and analyzed for MDA, vitamin C and Vitamin E by calorimetric method.
Results: The mean parity in group I was 2.4 and in group II was 2.7, BMI was 31.4 kg/m2 in group I and 29.5 kg/m2 in group II. The mean gestational age in group I was 32.5 weeks and in group II was 33.6 weeks. The mean MDA level in group I was 12.4 nmol/ml and in group II was 4.5 nmol/ml. The mean vitamin C level in group I was 0.31 mg/dl and in group II was 2.74 mg/dl. The mean vitamin E level in group I was 0.30 mg/dl and in group II was 0.95 mg/dl. The difference was significant (P< 0.05).
Conclusion: Higher level of MDA and decreased vitamin C and E level in pre- eclampsia patients is indicative of oxidative stress.
Key words: Pre- eclampsia, vitamin C, vitamin E level.