Background: Lichen planus (LP) is a common, chronic inflammatory mucocutaneous disease of unknown etiology and putative autoimmune pathogenesis. The present study compared tacrolimus and clobetasol in management of oral lichen planus. Materials & Methods: This study was conducted on 58 cases of clinically and histopathological confirmed cases of oral lichen planus. Patients were divided into 2 group of 29 each. Group I patients were given tacrolimus (0.1%) cream for 3 weeks and group II patients were given topical application of clobetasol propionate (0.05%) for 3 weeks. Pain on VAS and size of the lesion was recorded at baseline, after 3 weeks and 5 weeks. Results: The mean VAS at baseline, 3 wees and 5 weeks was 2.5, 1.2 and 0.4 in group I and 2.8, 1.7 and 0.9 in group II respectively. The mean size (cm2) at baseline, 3 weeks and 5 weeks in group I was 5.4, 3.1 and 1.2 and in group II was 4.9, 3.5 and 1.4 respectively. Conclusion: Authors found that tacrolimus (0.1%) cream is more effective than clobetasol propionate (0.05%) in the cases of oral lichen planus.
Key words: Clobetasol propionate, Oral lichen planus, Tacrolimus