Background- The main objectives in the management of OA are to reduce symptoms, minimize functional disability, limit the progression of structural changes and ultimately delay or avoid arthroplasty. Aims and Objectives- To check the efficacy and safety of rosehip extract in patients with osteoarthritis of knee. Materials and methods- The patients were randomized by employing randomization software. The patients reporting to Orthopaedics OPD with knee pain were screened for OA. Prior to intervention, a detailed clinical history, physical examination and baseline investigations were carried out. The selected patients with mild to moderate OA diagnosed according to ACR guidelines were enrolled for study. Results- More improvement in joint pain, stiffness and physical function was observed in Group 1 patients as compared to Group 2 patients (p<0.001) at 4, 8 and 12 weeks respectively. Conclusion-Both the groups were comparable as far as safety is concerned and ADRís reported didnít require any discontinuation of therapy. The results of our current study are very encouraging in favour of market preparation of rose hip extract as an adjuvant in patients of osteoarthritis of knee.
Keywords- Glucosamine, Chondroitin sulphate, Diacerin, disease modifying osteoarthritic drugs, articular cartilage.