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Volume 8 Issue 1 (January, 2020)

Original Articles

Assessment of levels of TNF-α in patients undergoing fixed orthodontic treatment
Neha Chandel, Prabhat Mandhotra, Tarush Thakur, Aprajita Dogra, Arun Patiyal, Anuj K Sharma

ABSTRACT: Background: Orthodontic forces cause an initial inflammatory response followed by alterations in the vascular and neural envelope and perpetual bone and tissue remodelling accompanied by paracrine release of bioactive mediators. The pro-inflammatory cytokines include Interleukin 1b (IL-1 b), IL-2, IL-5, IL-6, IL-8, interferon γ (IFN γ), tumor necrosis factor alpha (TNFα) and granulocyte macrophage colony stimulating factor (GM-CSF), which induce classic inflammation markers. Hence; the present study was conducted for assessing the levels of TNF-α in patients undergoing fixed orthodontic treatment. Materials & methods: A total of 20 patients scheduled to undergo fixed orthodontic treatment were enrolled in the present study. Complete demographic details of all the patients were obtained. During the pre-treatment phase, all the patients were recalled in the morning and GCF samples were obtained. All the samples were sent to laboratory where auto-analyser was used for assessing TNF-α level. Assessment of TNF-α levels was done one month after starting of the fixed orthodontic treatment and six months after starting of the fixed orthodontic treatment. Results: Mean TNF- α level at pre-treatment, one month post-treatment and six months post-treatment were found to be 6.72 pg/mL, 6.51 pg/mL and 6.59 pg/mL respectively. In the present study, while comparing the mean TNF- αs at different time intervals, non-significant results were obtained. Conclusion: Fixed orthodontic treatment doesn’t alter the TNF-α levels. Key words: Fixed orthodontic treatment, Tumour necrosis factor

 
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