Standard approach to the treatment of head and neck cancer include surgery, chemotherapy, and radiation. More recently, dramatic increases in our knowledge of the molecular and genetic basis of cancer combined with advances in technology have resulted in novel molecular therapies for this disease. In particular, gene therapy, which involves the transfer of genetic material to cells to produce a therapeutic effect, has become a promising approach. The aim of this review is to analyse the different modalities of gene therapy currently used to manage precancerous and cancerous lesions of the oral cavity.
Keywords: Squamous cell carcinoma, gene therapy, viral vectors.