Background: Periodontal disease is the most common localized dental inflammatory disease caused by bacterial infection of the periodontal cavity associated with subgingival plaque. Interleukin-17 (IL-17) is a proinflammatory cytokine secreted by Th-17 cells. It is a powerful activator of neutrophils as it regulates G-CSF and its receptor and chemokine expression. Hence; the present study was undertaken for assessing salivary IL-17 levels in periodontitis patients. Materials & methods: A total of 45 chronic periodontitis patients and 45 healthy controls were included in the present study. All the patients were recalled in the morning and salivary samples were taken. All the samples were sent to laboratory where an auto-analyser was used for evaluation of serum IL-17 levels. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software. Results: Mean IL-17 levels among the patients of the chronic periodontitis group and the control group was found to be 8.13 pg/ml and 1.39 pg/ml respectively. Significant results were obtained while comparing the mean IL-17 levels among the patients of the periodontitis group and the control group. Conclusion: IL-17 levels are raised significantly in periodontitis patients.
Key words: Interleukin, Periodontitis