Background: Peri-implant disease is a chronic inflammatory condition caused by bacterial plaque contamination. C reactive protein (CRP) is considered an acute-phase reactant and was shown to induce the expression of cellular adhesion molecules, thus mediating the adhesion of leukocytes to the vascular endothelium. Hence; the present study was conducted by assessing C Reactive proteins levels in patients with peri-implantitis. Materials & methods: A total of 120 patients were enrolled and were broadly divided into two study groups with 60 patients in each group as follows: Group A: Peri-implantitis patients, and Group B: Healthy controls. Complete demographic details of all the patients were obtained. Fasting blood samples were obtained from all the patients and were sent to central laboratory where an auto-analyzer and ELISA was used for assessing the CRP levels. All the results were recorded in Microsoft excel sheet and were analyzed by SPSS software. Mann-whiten U test was used for evaluation of level of significance. Results: Mean CRP levels among patients of group A and group B was found to be 401.8 pg/ml and 198.4 pg/ml respectively. On statistical analysis, it was observed that peri-implantitis patients had significantly higher levels of CRP in comparison to the healthy controls. Conclusion: Peri-implantitis patients had significantly higher levels of CRP highlighting their role in the pathogenesis of the disease.
Key words: Peri-implantitis, C reactive proteins