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Volume 5 Issue 5 (May, 2017)

Original Articles

Prevalence of Gastrointestinal Symptoms in Patients with Chronic Renal Failure
Anurag Srivastava, Deepak K. Gautam, Pankaj Mishra

Introduction: Gastrointestinal (GI) complications are well known to occur in patients with renal disease. A proper GI assessment is of paramount importance for a prospective renal transplant candidate as well as for patients having minor GI symptoms when they are on maintenance hemodialysis or conservative management of chronic renal failure (CRF). Aim: To assess the prevalence of GI symptoms in patients with CRF. Material and methods: A total of 60 chronic kidney disease (CKD) patients were included in the study. All these patients were evaluated on the basis of clinical data which were collected from patient’s medical records. Mucosal biopsies from the patients were examined at two levels using hematoxylin and eosin stain. Additionally, Giemsa stain was used in all gastric biopsies for the identification of Helicobacter pylori. Results: The majority of patients belonged to 30-60 years’ age group. Type 2 diabetes mellitus and hypertension were the most common comorbidity. A total of 41 (68.3%) patients presented with GI symptoms, which included dyspepsia, vomiting, dysphagia, chronic anemia and melena, and underwent esophagogastroduodenoscopy (OGD) followed by biopsy. Most common finding on biopsy was acute inflammation of esophageal mucosa with ulceration in 11 cases (18.33%). Conclusion: We conclude that the prevalence of GI symptoms is high in patients with CRF. Type 2 diabetes mellitus and hypertension were the most common comorbidity. Ulcerative and erosive esophagitis were the commonest findings in our study. Key words: chronic renal failure, gastrointestinal complications, malnutrition, esophagitis

 
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