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Volume 8 Issue 4 (April, 2020)

Review Articles

Specific Co-Relation between Bacille Calmette-Guérin Vaccine and Coronavirus
Pranoti Hiralkar, Urooj Fatima, Muqthadir Siddiqui Mohammed Abdul, Sunil Kumar Gulia, Nupur Shah, Glorymol Raju, Rahul Vinay Chandra Tiwari

The Bacillus Calmette-Guerin vaccine (BCG vaccine) intended to prevent tuberculosis in children and has been shown to induce a trained immune response in the body to fight against bacteria as well as other parasites and viruses. This knowledge has been shared to generate the idea that this vaccine can also offer protection against severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Some current articles have highlighted that countries with mass BCG immunizations seems to have a lower incidence of coronavirus disease 2019 (COVID-19) related to those without BCG immunization. There are yet no experimental proof of any such association and the world health organisation (WHO) is presently testing the theory with clinical trials on selected cohorts. Additional trials are required to back the claim that while waiting for a specific vaccine to be developed, BCG can serve as an alternative to boost non-specific immunity. Key words: coronavirus, trained immunity, live attenuated vaccine, BCG.

 
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