Journal of AdvancedMedical and Dental Sciences Research

Methotrexate (MTX) is the cornerstone of treatment in rheumatoid arthritis (RA). It has already been used for over 40 years as an anchor treatment in a number of rheumatic diseases, thereby; it remains a gold standard of therapy for RA. The weekly low dose MTX provides a cost effective, efficacious and generally well tolerated treatment for RA. The physicians should be aware of the risks associated with MTX use and must monitor accordingly. The present review provides a concise discussion of the toxicity and safety of methotrexate in treatment of rheumatoid arthritis. Key words: Rheumatoid arthritis, MTX toxicity, MTX treatment.