Journal of AdvancedMedical and Dental Sciences Research

Introduction: The careful choice of anesthetic agents in pediatric anesthesia reduces the frequency of anesthesia related complications. The objective of this study was to compare the intra operative and postoperative complication rates of propofol based anesthesia versus sevoflurane based anesthesia in cases of pediatric cleft lip, palate, alveolus surgery. Material and methods: 77 children from age group of 6months -12 years undergoing cleft lip, palate and alveolus surgeries were included in the study. They were divided in two groups, propofol group (n=37) were induced with propofol (2- 3mg/kg), fentanyl (2µg/kg) and vecuronium (0.1mg/kg), the anesthesia was maintained with propofol according to defined parameters. Sevoflurane–fentanyl group (n=40) was induced (5-8%) and maintained (0.8-1%) sevoflurane, supplemented with vercuronium and fentanyl. Both groups demographic data, hemodynamics and respiratory parameters were compared. Results: Hemodynamic parameters (Hb, HR) and SpO2 showed no significant difference in both groups. Emergence agitation was significantly higher in sevoflurane group (n=11) as compared to propofol group ( n=3). There were more reported cases of nausea/vomiting in sevoflurane group (n=12) as compared to propofol group (n=2) Conclusion: Propofol based anesthesia is safer than Sevoflurane based anesthesia regarding occurance of emergence agitation and nausea/ vomiting Key words: Propofol, Sevoflurane, Cleft lip and Palate