Aims-The study has been carried out to find the any correlation between changes in Lipoproteins and C - reactive protein with CD4 cell counts in HIV Positive patients. Materials and methods- The study was conducted at Department of Medicine, Pt. J. N. M. Medical College And Dr. B. R. Ambedkar Memorial Hospital, Raipur during the period of September 2012 to October 2013 on 100 HIV positive patients, of which 62 were males and 38 were females. Lipid profiles, C-reactive protein, CD4 cell count and other routine investigations were also done for all the patients. Results- In this study, of 100HIV positive patients, are grouped according to the CD4 cell counts in four groups, group I CD4 count <200/μL, group II CD4 count 201-350/μL, group III CD4 count 351-500/μL, and group IV has CD4 count>500/μL. Most patients with decreased CD4 count were found increased CRP level. Shows there is significant inverse correlation between CRP and CD4 count, as there is CD4 count decreases, the CRP level increases. It indicates as increase in severity of HIV infection associated with reduction in CD4 count, CRP level increases. We also observed serum level of total cholesterol, High density lipoprotein, were found to be decreased in HIV positive patients and on the other hand, the level of Very low density lipoprotein is increased as there is reduction of CD4 cell count. There is no significant change found in serum Triglycerides and low density Lipoprotein in relation with CD4 cell count. Conclusion- In the present study, lipid profile and C-reactive protein was altered in HIV positive patients with decreased CD4 count. Monitoring of lipid profile and C-reactive protein can be a good index of disease progression, management and cardio vascular risk assessment in HIV/AIDS patients in the absence of CD4 cell count facility.
Key words: HIV, AIDS, CD4 cell count, C-reactive protein, Lipoproteins, lipid profile.
Corresponding Author: Dr. Prakash Khunte, MD (General Medicine), Assistant Professor, Department of Medicine, BRLSABVM, Government Medical College & Hospital, Rajnandgaon, Chhattisgarh
This article may be cited as: Patel GS, Khunte P, Khunte S, Rangari P. Lipoproteins and C- Reactive Protein Abnormalities in HIV Positive Patients and their correlation with CD4 Cell Counts. J Adv Med Dent Scie Res 2020;8(1):45-51.