Journal of AdvancedMedical and Dental Sciences Research

Background: Thyroid cancer begins in the follicular cell of the thyroid gland. The present study was conducted to assess immunohistochemistry of thyroid carcinoma. Materials & Methods: The present study was conducted on 62 specimens of throid. Hematoxylin- and eosin-stained sections were classified into three groups. 40 were of WDT-UMP (Group 1), 14 cases were of PTC, and 8 cases were of FVPTC. With 40X objective lenses, >10% positive follicular cells showed membranous and cytoplasmic staining was considered positive for CD56 and CK19, as well as >10% of the nuclear staining of the follicular cells were considered positive for P63. Results: Out of 62 specimens, 24 were of males and 38 were of females. 7 cases of WDT- UMP, 8 of PTC and 10 of FVPTC were positive of CD56, 42 of WDT- UMP, 45 of PTC and 38 of FVPTC were p63 positive and 30 WDT- UMP, 34 of PTC and 42 of FVPTC were CK 19 positive. The mean nuclear area in WDT-UMP was 48.1, PTC was 52.4 and FVPTC was 50.6. Mean nuclear perimeter in WDT-UMP was 28.3, PTC was 28.5 and FVPTC was 29.6. The difference was non- significant (P> 0.05). Conclusion: Authors found that WDT-UMP are intermediate lesions seen in thyroid specimens. Key words: Thyroid, CD56, WDT- UMP.