Journal of AdvancedMedical and Dental Sciences Research

Background: Oral Submucous Fibrosis is a chronic progressive debilitating disease of the oral mucosa involving the oropharynx. The present study was conducted to assess efficacy of intralesional injection of Hyaluronidase and Triamcinolone in treatment of OSMF. Materials & Methods: The present study was conducted on 68 patients of OSMF of both genders. Patients were given intralesional injection of 1500 IU hyaluronidase (1 ml) and triamcinolone 40 mg (1 ml) mixed with 2% lignocaine with adrenaline (1:200,000) at the interval of ten days. Patients were recalled regularly intervals of 2 weeks, 1, 3 and 6 months. Mouth opening was recorded. Results: Out of 68 patients, males were 56 and females were 12. Mouth opening before treatment in males was 20.6 mm and in females was 24.2 mm, after 1 month was 22.1 mm in males and 25.6 mm in females, after 2 months was 26.8 mm in males and 30.4 mm in females, after 3 months was 35.4 mm in males and 38.1 mm in females and after 6 months, it was 38.6 mm in males and 41.2 mm in females. The difference was significant (P< 0.05). Conclusion: Authors found that combination of intralesional injection of Hyaluronidase and Triamcinolone in treatment of OSMF found to be effective. Key words: Hyaluronidase, OSMF, Triamcinolone