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Volume 7 Issue 9 (September, 2019)

Original Articles

Clinicopathologic profile in Multiple Myeloma- A case series of 30 cases
Harsh Jakhetia

Objective: To evaluate the clinicopathological features of multiple myeloma at a tertiary centre hospital and aid further to the prevailing knowledge of the disease. Method: We retrospectively analysed 30 newly diagnosed patients with multiple myeloma over a period from 2007 to 2015. Diagnosis of new cases was based on the Salmon and Durie criteria which included Plasmacytoma – on biopsy, Bone marrow plasmacytosis>30% plasma cells, M band in serum (IgG >3.5 g/dl or IgA > 2g/dl) as major criteria. Results: The study included 19 males and 11 females. Mean age of patient was 52 years with a range from 16 to 75 years. Common clinical features included bone pain (83%), weakness/fatigue( 73%), backache (60%), pallor (53%) and pathologic fracture (40%).common laboratory features and radiologic features included anaemia (77%),bence-jones proteinuria(57%), lytic bone lesions (53%),hyperglobulinemia ( 47%),Raised LDH( 40%),hypercalcaemia (37%),raised creatinine (30%). The most common gammopathy was found out to be IgG (80%).Bone marrow plasmacytosis (>30%) was seen in 67% of the patients. Conclusion: Multiple myeloma not being an infrequent condition, hence the knowledge of common clinical, radiologic and pathological features helps in the early, unerring diagnosis and thus better management of the condition. Key words: Multiple myeloma; Bone marrow plasmacytosis

 
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