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Volume 7 Issue 8 (August, 2019)

Original Articles

Comparative analysis of efficacy of Fluconazole and Nystatin incorporated into Tissue Conditioner as drug delivery method for denture stomatitis
Vinay Kumar K, Akshatha LN, Shwetha Nagraj, Suhas H G, Satyajit S Topajiche

Background: Denture stomatitis is a pathological condition of the denture bearing mucosa caused by trauma from ill-fitting dentures. It is characterized by generalized inflammation or reddening of the palatal mucosa underneath the denture and more prevalent in complete denture wearers. The etiology of denture stomatitis can be multifactorial however, the infection by Candida species especially the Candida albicans (C. albicans), is considered to be the main etiologic factor. Treatment plan should include substitution of old prosthesis, elimination of anatomical irregularities, establishment of a nontraumatic occlusion, nutritional reconstitution, oral hygiene instructions, antifungal treatment, and systemic evaluation. The limitations have led to the development of other methods of drug elution such as incorporation of antifungal and antimicrobial agents with denture soft liners. Aim of the study: To compare the efficacy of Fluconazole and Nystatin incorporated into Tissue Conditioner as drug delivery method for denture stomatitis. Materials and methods: The present study was conducted in the department of prosthodontics of the dental institution.  Candida albicans was cultured onto Sabouraud dextrose agar plate and incubated at 37ºC for 3 days.  All disks were contaminated with 100 μl of 1 × 10 6 CFU/ml C. albicans cell suspension and the cell culture plate were incubated at 35ºC on a rotary shaker for 48 hours. The plates were incubated at 37ºC for 48 hours and the colonies were enumerated. The data was tabulated for further evaluation.Results: We observed that that Nystatin 5% solution was the most efficient for inhibiting attachment and colonization of C. albicans (0.22). Fluconazole 5% solution is partially effective efficient for inhibiting attachment and colonization of C. albicans. The control solution was least effective with highest Candida density seen in control solution.Conclusion:Within the limitations of present study, we conclude that the incorporation of nystatin incorporated into tissue conditioners is more effective in treatment of chronic atrophic candidiasis in denture users as compared to Nystatin.
Keywords:  Fluconazole, Nystatin, Tissue conditioners, Stomatitis.

Received: 11 June, 2019                             Revised:  12 July 2019                              Accepted: 14 July 2019

Corresponding Author: Dr. Shwetha Nagraj, Associate professor, Department of Biochemistry, Shridevi Institute of  Medical Science and Research Hospital Tumkur

This article may be cited as: KK Vinay, LN Akshatha, Nagraj S, H G Suhas, Topajiche SS. Comparative analysis of efficacy of Fluconazole and Nystatin incorporated into Tissue Conditioner as drug delivery method for denture stomatitis. J Adv Med Dent Scie Res 2019;7(8):263-266.

 
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