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Volume 7 Issue 8 (August, 2019)

Original Articles

Evalution of Serum Lipid Profile in Head and Neck Cancer, OSMF and Leukopkia Patients
Tarun Vyas, Parnika Kuthiala, Niharika Sarathy, Ankita Bansal, Sunaina Singla

Background:
The lipids are important ingredients of cell membranes and play a vital role in numerous biological processes, including maintaining the integrity of the cell. Materials & Methods: In the perspective of this view, influences on levels of various serum lipid profile parameters, namely, Total cholesterol (TC), LDL cholesterol, VLDL cholesterol, HDL cholesterol, Triglycerides (Trg) have been discussed with an aim to correlate & evaluate plasma lipid profile in head  & neck cancer, oral submucous fibrosis, leukoplakia and normal control group.  Result: The lower plasma lipid status may be a useful indicator for initial changes occurring in neoplastic cells. Plasma TC, HDL, LDL and TG values were lower in squamous cell carcinoma. OSMF and leukoplakia patients than healthy individuals. The most reduced levels are present in cancer patients while OSMF and Leukoplakia patients have similar levels. There was statistically significant difference present in lipid profile of OSMF, leukoplakia and squamous cell carcinoma patients than in normal groups. There was no statistically significant  difference present between lipid profile of OSMF and leukoplakia patients. Lipid profile of squamous cell carcinoma was lower than OSMF patients. Lipid profile of squamous cell carcinoma was lower than leukoplakia patients. Conclusion: Plasma lipid profile levels may be a useful indicator reflecting initial changes occurring in pre-cancerous and neoplastic conditions. The lower plasma lipid status may be useful bio-marker indicator for initial  change occurring in neoplastic cells.
Key words: High density lipid, Lipid profile parameters, Low density lipid, Cholesterol.
 
Received: 13 March, 2019                                         Revised:  10 June 2019                             Accepted: 12 June 2019

Corresponding author: Dr. Tarun Vyas, Assistant professor, Department of Oral Medicine  and Radiology, R R Dental College & Hospital, Umarda, Udaipur (Rajasthan), India
               
This article may be cited as: Vyas T,  Kuthiala P, Sarathy N, Bansal A, Singla S. Evalution of Serum Lipid Profile in Head and Neck Cancer, OSMF  and Leukopkia Patients. J Adv Med Dent Scie Res 2019;7(8): 10-19.

 
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