Journal of AdvancedMedical and Dental Sciences Research

Background: This study was done to evaluate the level of alkaline phosphatase  as potential biochemical gingival crevicular fluid marker among chronic periodontitis patients with smoking habit. Materials and methods: A total of 80 subjects were selected for the study. The study population was further divided into 4 group (Group 1 – clinically healthy periodontium, Group – 2 gingivitis, Group – 3 periodontitis and Group - 4 smokers with periodontitis) .Based on clinical  assessment of  probing depth , bleeding on probing and radiographic evaluation of alveolar bone loss , gingival crevicular fluid samples were taken to assess the level of enzymes . Results: Obtained results shows statistically significant increase in the level of alkaline phosphatase activity in gingival crevicular fluid from periodontitis patients with smoking habit . There was positive correlation between the activity of examined gingival crevicular fluid enzymes and values of the plaque index ,  gingival index and periodontal disease index. Conclusion: Based on these results, it can be assume that alkaline phosphatase  activity  in gingival crevicular fluid may be used as potent biochemical markers for periodontal destruction.
Key words: Alkaline phosphatase, Gingival crevicular fluid, Periodontitis , Smokers.

Received: 13 March, 2019                                         Revised:  22 April 2019                             Accepted: 25 April 2019
                        
Corresponding author: Dr. K. Hameed Fathima, Assistant Professor, Department of Dentistry, 1Sri Muthukumar Medical College hospital and Research Institute, Chennai India
               
This article may be cited as: Fathima KH, Harish VS Evaluation of Alkaline Phosphatase in Gingival Crevicular Fluid  among  Chronic Periodontitis Patients with  Smoking Habit. J Adv Med Dent Scie Res 2019;7(7): 163-167.