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Volume 7 Issue 6 (June, 2019)

Original Articles

Assessment of Expression of Myofibroblast in Oral Squamous Cell Carcinoma Patients
Namita Sepolia, Shubhangi Mahajan

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Myofibroblasts exhibit a phenotype between fibroblasts and smooth muscle cells. Hence; under the light of above mentioned data, we planned the present study to assess the expression of myofibroblast in oral squamous cell carcinoma patients. Materials & method: A total of 20 normal healthy controls were included in the present study. Histopathologic sections of all the OSCC cases and normal healthy controls were obtained and were stained with H and E stain. We included those cases as normal healthy controls which were scheduled to undergo orthodontic dental extractions. Immuno-histochemical staining was done in all the 40 sections using alpha- Smooth muscle actin (α-SMA) antibody.  Staining index for each group was calculated and compared. All the results were recorded in Microsoft excel sheet and were analyzed by SPSS software.  Results: Mean staining index score in the OSCC group and control group was found to be 8.41 and 0 respectively. Significant results were obtained while comparing the mean staining index score in between the OSCC group and the control group. Conclusion: Myofibroblast play a definitive role in the invasive behavior of OSCC.
Key words: Oral squamous cell carcinoma, Myofibroblast

Received: 12 May, 2019                            Revised:  29 May 2019                             Accepted: 30 May 2019

Corresponding author: Dr. Namita Sepolia, MDS, Private consultant, J & K, India.

This article may be cited as: Sepolia N, Mahajan S. Assessment of Expression of Myofibroblast in Oral Squamous Cell Carcinoma Patients. J Adv Med Dent Scie Res 2019;7(6): 38-40.

 
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