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Volume 7 Issue 5 (May, 2019)

Original Articles

Effectiveness of proton pump inhibitor (Rabeprozole) in nonerosive reflux disease- a prospective placebo-controlled study
Hakim Mohammad Shafi, Showkat Hussian Shah, Aijaz Ahmad Hakeem

Introduction: Nonerosive reflux disease is defined as the presence of typical symptoms of gastroesophageal reflux disease in absence of visible esophageal mucosal injury at endoscopy. 24 hour ph study is needed to define the sub group. Treatment with the acid inhibitory agents is effective, proton pump inhibitors are most effective form of therapy. Clinical results to date suggest that antisecretory therapy may be less effective in providing symptom relief for the patients nonerosive reflux disease than the patients with erosive disease. Material and Methods: A total of 101 patients with nonerosive reflux disease were randomized to receive placebo (49) or rabeprozole (52) for 6 months, with consultations at 3 weeks, 6 weeks, and 6 months. The primary end points were change in the severity of heart burn and regurgitation at the above mention period. Demographics of the randomized in each group were comparable. Results: The baseline characteristics between two groups were similar.At 3 weeks and six weeks, treatment group showed greater reduction of VAS for heart burn(p<0.01).  However there was no significant difference between the placebo and rabeprozol group at 6 weeks and 6 months. Around 56.43% patients showed demesseter’s score more than than 20 and where consider to have positive 24 hour ph study. Patients who had positive 24 hour  ph study  responded moderately well to Rabeprozole (59.61%) compared to placebo, Patients on placebo showed only mild response in only 20.40%  patients and 79.59% patients had no response.  Conclusion: Rabeprozole was more effective than placebo of the treatment of symptoms presented by the patients with nonerosive reflux disease, who had positive 24 hour ph study. From the observations of the present study it could be concluded that Among GERD, Nonerosive reflux disease more common than erosive esophagitis. Nonerosive reflux disease is a heterogeneous disorder comprising three different groups, Haitus hernia less common endoscopic finding in nonersive reflux disease. From the present study it is concluded that Rabeprazole is effective in controlling the symptoms in NERD patients and effect of the drug is better than the placebo in the patients who had positive ph study which was defined by Demesseter’s score more than 20.
Key words: Proton pump inhibitor,  non erosive reflux disease.

Received: 26 February, 2019                  Revised: 29 March, 2019                        Accepted: 30 March, 2019

Corresponding Author: Dr. Hakim Mohammad Shafi, Consultant Medicine, Govt. Medical College Anantnag, Jammu and Kashmir, India;

This article may be cited as: Shafi HM, Shah SH, Hakeem AA. Effectiveness of proton pump inhibitor (Rabeprozole) in nonerosive reflux disease: a prospective placebo-controlled study.  J Adv Med Dent Scie Res 2019;7(5): 68-74.

 
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