Categories
Volume 6 Issue 1 (January, 2018)
Original Articles
Assessment of Activity of Serum Beta-galactosidase in Colon Cancer Patients- A Pathological Study | |
Himanshu Chauhan | |
Background: Colorectal carcinomas are one of the most frequent neoplasms in Western society. Lysosomal-β-galactosidase is a lysosomal enzyme that hydrolyzes the terminal β-galactose from ganglioside substrates and other glycoconjugates. Hence; we planned the present study to assess the activity of serum beta-galactosidase in colon cancer patients. Materials & methods: We planned the present study to assess of the activity of serum beta-galactosidase in colon cancer patients. A total of 10 colon patients and 10 healthy controls were included in the present study. We assessed the activity of β-galactosidase in the serum (pkat/ml) in duplicate by the colorimetric determination of p-nitrophenol released from p-nitrophenyl-β-D galactopyranoside by β-galactosidase. All the results were analyzed by SPSS software. Chi- square test was used for assessment of level of significance. Results: Mean activity of serum β-galactosidase in the patients of the study group and control group were 77.5 and 69.5 pkat/ml respectively. However; we didn’t observe any significant difference while comparing the mean serum β-galactosidase levels in between subjects of study group and the control group. Conclusion: β-galactosidase activity remains unaltered in colon cancer patients. |
|
Abstract View | Download PDF | Current Issue |