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Volume 3 Issue 1 (January - March, 2015)

Review Articles

INHIBITORS OF APOPTOSIS- STRONG SUPPORTERS FOR ORAL CANCER PROGRESSION
Vivek Javagal, Harishchandra Rai

Department of Oral Pathology and Microbiology, K.V.G Dental College and Hospital, Sullia

Apoptosis is a physiological cell suicide program that is critical for the development and maintenance of healthy tissues. Dysregulation of apoptosis is known to occur in cancer and various other diseases. The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. Because of its upregulation in malignancy, it has become of great interest as both a tumor diagnostic and prognostic marker, as well as a new substantial biologic target for future anti-cancer therapies. Abundant literature is available on the structural aspect as well as the possible role of IAPs in various cancers and only few studies have been done in oral cancer. Hence, this review focuses on the role of IAPs in oral cancer.

Keywords: Apoptosis, caspase, cancer progression, anti-cancer therapy

Corresponding author: Dr. Vivek Javagal, Post graduate student, Department of Oral Pathology and Microbiology, K.V.G Dental College and Hospital, Sullia, Karnataka- 574 327, E-mail: drjavagal@gmail.com

This article may be cited as: Javagal V, Rai H.  Inhibitors of Apoptosis: Strong Supporters for Oral Cancer Progression. J Adv Med Dent Scie Res 2015;3(1):121-129.

 
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