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Volume 3 Issue 1 (January - March, 2015)

Review Articles

HIGH THROUGHPUT MOLECULAR PROFILING OF TUMOUR SPECIMENS- TISSUE MICROARRAY- A BRIEF REVIEW
Rumeet Kaur, Simranjot Kaur Dhillon, Tarandeep Kaur Pannu, Adesh S Manchanda, Japneet Kaur

1BDS (Intern), 2BDS, 3Senior Lecturer, Department of Oral & Maxillofacial Pathology, Sri Guru Ram Das Institute of Dental sciences & Research, Amritsar, Punjab, India.

Recent advances in the field of human molecular genetics have revealed gene based disease mechanisms in many areas of medicine. The study of new prognostic and diagnostic markers in large numbers of clinical specimens is an important step in translating the new findings from basic science to clinical practice. Tissue microarray is a recent innovation which facilitates analysis and bridges the gap between candidate discovery and candidate testing. They are routinely used molecular epidemiology, drug development, and determine the prognostic, diagnostic and predictive value of new biomarkers. This technology should not be confused with DNA microarrays where each tiny spot represents a unique cloned cDNA or oligonucleotide. In tissue microarrays, the spots are larger and contain small histologic sections from unique tumors or tissues. The purpose of this article is to review this increasingly popular technology, focusing on several technical aspects of tissue microarray applications.

Key words: Immunohistochemistry, Molecular profiling, Tissue micro arrays.

Corresponding Author: Dr. Adesh S Manchanda, MDS, Senior Lecturer, Department of Oral & Maxillofacial Pathology, Sri Guru Ram Das Institute of Dental sciences & Research, Amritsar, GT Road Punjab, India. Email:  adesh_manchanda@yahoo.com

This article may be cited as: Kaur R, Dhillon SK, Pannu TK, Manchanda AS, Kaur J.  High Throughput Molecular Profiling of Tumour Specimens- Tissue Microarray: A Brief Review. J Adv Med Dent Scie Res 2015;3(1):116-120.   

 
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