Background: There is a rich ANS supply to major organs of glucose metabolism which includes liver, pancreas and skeletal muscles. Therefore, ANS changes and metabolic alterations are linked to each other. Aim of the study: To assess the impact of cold stress on heart rate and blood pressure in healthy offspring with and without parental history of type II diabetes mellitus. Materials and methods: A total of 50 subjects were selected for the study, 25 patients were healthy and non-diabetic without parental history of T2DM; and other 25 patients were healthy and non-diabetic subjects with at least one parent with T2DM. A written informed consent was obtained from each patient before the study after verbally explaining to them the procedure of the study. Results: Mean age of study group was 20.20 years and control group were 19.80 years. Mean height in study group was 1.79 cm and in control group was 1.69 cm. Mean weight of study group was 63.28 kg and in control group was 65.87 kg. We observed that comparison of heart rate before CPT and during CPT at study group and control group was statistically non-significant. After CPT, the comparison of heart rate between study group and controls at various time intervals was statistically significant. Conclusion: The HR response to CPT was comparable, but after CPT the recovery of HR was smooth and gradual in the controls, whereas it was abrupt in cases.
Keywords: CPT,heart rate, ANS, Diabetes mellitus.