Probiotics are counterparts of antibiotic thus are free from concerns for developing resistance, further they are body's own resident flora hence are most easily adapted to host. With fast evolving technology and integration of biophysics with molecular biology, designer probiotics poses huge opportunity to treat diseases in a natural and non invasive way. Periodontitis have established risk of various systemic diseases like diabetes, atherosclerosis, hyperlipedemia, chronic kidney diseases, and spontaneous preterm birth.Thus, a critical need to establish good periodontal health for attaining good systemic health is of utmost importance and probiotics are promising, safe, natural, and side effects-free option, which are required to be explored in depth for periodontal application. Advances and accomplishments attained give us the ability to employ these friendly bacteria (probiotics) as nano soldiers in combating periodontal diseases. Despite great promises, probiotics works are limited to gut. Periodontal works are sparse and need validation by large randomized trials. It can be said probiotics are still in “infancy” in terms of periodontal health benefits, but surely have opened door for a new paradigm of treating disease on a nano – molecular mode.
Key words: Probiotics, Prebiotics Periodontal disease, Lactobacillus, Bifidobacterium.