Journal of AdvancedMedical and Dental Sciences Research

Background: Diabetes mellitus affects 2 to 10% of pregnancies, and most (about 90%) of diabetes in pregnancy are gestational diabetes. Pregnancy is a relatively “diabetogenic” state due to the increase in hormonal antagonists of the insulin (e.g. human placental lactogen) resulting in reduced tissue sensitivity to insulin. Aim of the study: To assess the impact of twin pregnancy on obsetetric and perinatal outcomes in diabetic females. Materials and methods: The present study was conducted in the Department of Obstetrics and Gyneclogy at MGM Hospital, Navi Mumbai, Maharashtra. Medical records were reviewed to identify women with pregestational DM (type 1 or type 2) who gave birth to twins between the study period. Diabetes was defined according to the classification of the American Association of Diabetes. The following obstetric and perinatal outcomes were analyzed: gestational age at delivery, prematurity (pregnancy duration b37 or b34 weeks), mode of delivery (vaginal or cesarean), and birthweight. Results: The mean age of the patients in type 1 DM cases was 31.25 years and in type 2 DM cases was 32.8 years. The mean BMI in Type1 and Type 2 DM cases was 24.25 and 27.32 respectively. Hypertensive complications were seen in 2 cases each in Type 1 and Type 2 DM. the number of patients admitted to NICU was 8 in Type 1 and 6 in Type 2 cases. The mean birthweight in Type 1 DM was 2471 g and was at 68th percentile. Conclusion: The risk of peri-natal morbidity increases in women with pregestational diabetes; however, non-significant difference was observed between Type 1 and Type 2 diabetes mellitus patients. Keywords: Diabetes mellitus, obstetrics, twin pregnancy.