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Volume 6 Issue 4 (April, 2018)

Original Articles

A Comparative Study of Cholesterol Levels in Rabbits fed with Oral Contraceptives and in Combination with Vitamin E
Inderjit Singh, Jasmeet Singh, K.C. Manchanda, Rupinderjit Kaur

Introduction : Cholesterol metabolism is influenced by many factors such as OCP’s having ethinyl estradiol along with levongestrel. These hormones influence cholesterol metabolism and its protective effect with supplementing Vitamin E was studied on rabbits. Aims & Objectives: The cholesterol levels were compared on the first day of study and on completion of 90 days of study on rabbits in all the 3 groups. In group A rabbits were fed only on stock diet. In group B the rabbits were fed on stock diet along with OCP’s and in Group C the rabbits were fed on stock diet along with OCP’s plus vitamin E and the changes in levels of serum cholesterol were recorded. Materials & Methods : The present study was conducted in the Department of Physiology Govt. Medical College, Amritsar and in collaboration with the Department of Physiology Chintpurni Medical College & Hospital, Bungal, Pathankot( CMC & H, Bungal, Patnankot. The practical work was done on rabbits at Govt. Medical College, Amritsar (G.M.C Amritsar) and study is being published at Chintpurni Medical College & Hospital, Bungal, Pathankot. Results: The cholesterol levels increased on addition of OCP’s to the stock diet but the levels were decreased on the addition of supplements like Vitamin E. Conclusions: The addition of OCP’s disturb lipid metabolism but it can be overcome by addition of supplements like Vitamin E. Key words: OCP’s (Oral Contraceptive Pills), HDL-C (High Density Lipoprotein Cholesterol)

 
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