Journal of AdvancedMedical and Dental Sciences Research

Background: Laproscopic cholecystectomy is the treatment of choice for cholelithiasis. Sometimes even after removal of gall bladder few complications arises. The present study was conducted to assess the utility of tranexamic acid in laparoscopic cholecystectomy. Materials & Methods: The present study was conducted on 52 patients of both genders (males- 38, females- 14). Patients were divided into 2 groups. Group I received intravenous dose 20 mg/kg of tranexamic acid at induction of anesthesia. Group II did not receive any trenaxamic acid. mean hospital stay was 3.2 days in group I and 3.4 days in group II, drain fluid hemoglobin was 0.92 gm% in group I and 0.98 gm% in group II, mean pulse rate 24 hours after surgery was 78.2 beats/ min in group I and 80.4 beats/min in group II. Mean change in hemoglobin. Results: Age group 20-40 years had 18 males and 7 females, 40-60 years had 12 males and 6 females and >60 years had 8 males and 1 female. The difference was significant (P<0.05). Common comorbidities was smoking seen in 12 in group I and 10 in group II, diabetes in 17 cases in group I and 6 in group II, hypertension seen 15 cases in group I and 7 in group II, alcoholic seen 5 in group I and 6 in group II and drug addiction 1 in both groups. Mean hospital stay was 3.2 days in group I and 3.4 days in group II, drain fluid hemoglobin was 0.92 gm% in group I and 0.98 gm% in group II, mean pulse rate 24 hours after surgery was 78.2 beats/ min in group I and 80.4 beats/min in group II. Mean change in hemoglobin was 0.28 gm% in group I and 0.30 gm% in group II. Conclusion: The blood loss is can be well controlled by tranexamic acid. Laproscopic cholecystectomy is widely used surgical procedure in cases of cholelithiasis. Key words: Cholecystitis, Diabetes, Tranexamic acid.