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Volume 7 Issue 2 (February, 2019)

Original Articles

Association of Serum gamma-glutamyl transferase with risk factors of Stroke
N.S. Neki, Aarti Vaid, A.S. Dhanju, Sukhraj Kaur, Bhawna, Puja Vaid, Vikas Lakhanpal

Background: Stroke entails a high socioeconomic burden due to increased morbidity and mortality and more commonly affects elderly patients who comprise a continuously increasing proportion of the population in developed countries. Ischemic stroke accounts for about 80% of total stroke events. There are several risk factors of stroke of which diabetes mellitus, hypertension, smoking, high cholesterol, atrial fibrillation, alcohol consumption, obesity, Family history of stroke are most important. Aim: To evaluate various risk factors associated with acute stroke patients and correlate them with serum gamma-glutamyl transferase GGT levels in both young and elderly population. Material and methods: a total sample of 200 patients were included which were grouped as  Group A as case population, comprising  of 100 patients with acute stroke and Group B as comtrol, comprising of 100 age and sex matched subjects without obvious cerebrovascular diseases. All were subjected to routine history taking particularly alcohol consumption, use of drugs, smoking, hypertension, diabetes mellitus, dyslipidemia, general physical examination, systemic examination, biochemical tests like Liver function test, Lipid profile, Blood sugar, Blood Urea and Serum Creatinine , serum GGT and lastly neuro-imaging (only for group A). Results: In young individuals, Serum GGT levels correlated positively with serum cholesterol, serum triglyceride, Serum HDL, LDL and VLDL. This association in comparison to Serum GGT levels was considered statistically significant. Difference of GGT levels when compared between in hypertensives and non hypertensives between both the groups came to be statistically significant. Conclusion: These correlations and findings helps us in focussing on specific interventions to manage blood pressure, smoking, lipid profile and promote physical activity and a healthy diet which could substantially help in reducing the burden of stroke.
Key Words: Acute stroke, risk factors, hypertension, serum GGT.

Received: 5 January  2019                                       Revised: 25 January 2019                              Accepted: 28 January 2019
Corresponding Author: Dr. Aarti Vaid, Department of Medicine, GMC Amritsar, Punjab, India
This article may be cited as: Neki NS, Vaid A, Dhanju AS, Kaur S, Bhawna, Vaid P, Lakhanpal V. Association of Serum gamma-glutamyl transferase with risk factors of Stroke. J Adv Med Dent Scie Res 2019;7(2):43-48.

 
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