Journal of AdvancedMedical and Dental Sciences Research

Background: Obesity is a multifaceted condition and represents a pandemic that needs urgent attention. Leptin most likely indicates satiety and fullness of energy stores under physiological conditions, but obesity is characterized by hyperleptinemia and hypothalamic leptin resistance. The present study was conducted to assess the relation between leptine hormone disturbance and lipid level disorders in obese. Materials & Methods: It comprised of 156 subjects of both genders. All were divided into 3 groups. Group I (Control) comprised of 56 subjects with BMI (18.5-24.9 kg/m2). Group II (Overweight) consisted of 55 with BMI (25.0–29.9 kg/m2). Group III (Obese) consisted of 45 with BMI (≥ 30 kg/m2). Serum Leptin was measured by ELISA. Serum GSH, serum MDA and serum lipid profile were measured by spectrophotometer. Results: BMI (kg/m2) in group I was 23.21±1.2, in group II was 26.72±1.5 and in group III was 35.46±1.1. The difference was significant (P-0.01). Leptin level (ng/ml) in group I was 12.22±1.8, in group II was 27±2.5 and in group III was 33±6.3. The difference was significant (0.03). GSH (μmol/L) level in group I was 4.1±1.0, in group II was 3.25±2.1 and in group III was 1.6±1.2. The difference was significant (0.01). MDA (μmol/L) level in group I was 7.9±1.5, in group II was 12.662±1.4 and 14.12±2.4 in group III. The difference was significant (0.001). Cholesterol level was 4.2 mmol/l in group I, 5.1 mmol/l, in group II and 5.8 mmol/l in group III. Triglyceride level was 1.5 mmol/l in group I, 2.3 mmol/l in group II and 3.1 mmol/l in group III. HDL level was higher in group I (2.3 mmol/l), group II (1.6 mmol/l) and group III (1.08 mmol/l). LDL level was lower in group I (1.4 mmol/l), group II (2.7 mmol/l) and group III (3.6 mmol/l). VLDL level was 0.8 mmol/l in group I, group II (1.2 mmol/l) and group III (1.5 mmol/l). Group III had higher VLDL level. Conclusion: There was a significant increase in the levels of leptin. There was a significant increase in the levels of BMI, MDA, TC, triglycerides, LDLC and VLDL and decrease in the level of GSH and HDL in overweight and obese individuals.
Key words: Cholesterol, Leptin, Obesity.