Background: Oral submucous fibrosis is a perpetual dynamic ailment of the oral cavity with capability of threatening malignancy formation. For the treatment of this pathologic condition, an extensive variety of modalities comprising of medication administration, surgical treatment, and physiotherapy have been endeavored till date; with shifting degrees of advantage, yet none of them have turned out to be a cure for this ailment. Subsequently, we arranged this investigation to analyze the viability of Levamisole and Colchicine in the treatment of oral submucous fibrosis against the Hyaluronidase injections. Existing medicines give just transitory symptomatic help. Colchicine is an old medication with strong action against fibrotic and inflammatory properties. Materials and Methods: The present examination included an evaluation of OSMF patients who experienced treatment by Levimasole and Colchicine against the Hyaluronidase injections. Every one of the 60 patients were isolated arbitrarily into two examination gatherings. Gathering A included patients who were given Levimasole and Colchicine thrice day by day by oral route and gathering B included patients who were given Hyaluronidase injections once a week alternatively. Records of the considerable number of readings and estimations of the patients previously beginning of the treatment and amid the subsequent time were kept up. Every one of the outcomes were broke down by the analytical team. Results: The mouth opening amid the primary follow-up period toward the finish of first month of treatment among the Group A and Group B patients was noted. Noteworthy outcomes were acquired while looking at the mean mouth opening in both the gatherings at various interim of time. Both groups showed relief from burning sensation as well. Conclusion: Significant diminishment in the mouth opening of the patients happens with both Levimasole and Colchicine and Hyaluronidase injections.
Key words: OSMF, Levimasole and Colchicine, Hyaluronidase injections.
Corresponding author: Dr. Nikan Makadia, BDS, College Of Dental Sciences & Research Centre, Ahmedabad, Gujarat, India.
This article may be cited as: Sheth M, Makadia N, Patel N, Patel M, Patel DK, Patel B. Evaluation of Two Different Treatment Modalities for the Management of Oral Submucous Fibrosis: A Relative Report and Analysis. J Adv Med Dent Scie Res 2017;5(12):8-10.