Journal of AdvancedMedical and Dental Sciences Research

Background: Tuberculosis (TB) is one of the common causes of deaths occurring worldwide. Multidrug-resistance (MDR) is one of the commonest forms of TB encountered these days. Resistance due to drugs are bringing the need for their replacement with drugs of higher generation. Hence; we planned the present study to assess and compare the efficacy of levofloxacin or moxifloxacin on the outcome of MDR-TB. Materials & methods: The present retrospective study included assessment of efficacy of levofloxacin or moxifloxacin on the outcome of MDR-TB. Complete reviewing of data records of the age, body mass index (BMI), demographic, clinical and radiographic details of all the patients was done. We also assessed the details of the treatment therapy along with dosage of all the patients form their record file. Laserson et al. criteria were used for the assessment of outcome of the treatment.All the results were analyzed by SPSS software. Results: A total of 120 subjects were included in this retrospective study. 45 cases in the levofloxacin group and 47 cases in the moxifloxacin group had successful treatment outcome whereas in 10 and 7 cases of the levofloxacin and moxifloxacin group respectively, failure of treatment occurred. Non- significant results were obtained while comparing the outcome of treatment in both the study groups. Conclusion: Similar treatment outcome occurs in patients treated with either levofloxacin or moxifloxacin therapy.
Key words: Levofloxacin, Moxifloxacin, Tuberculosis.

Corresponding author: Dr. Kanhaiya Prasad, Associate Professor, Department Of Medicine, GCRG Medical College Bakshi ka talab, Lucknow, U.P., India

This article may be cited as: Singh S, Prasad K. Assessment of efficacy of levofloxacin and moxifloxacin on outcome of multidrug-resistant tuberculosis treatment: A comparative retrospective study. J Adv Med Dent Scie Res 2017;5(7):71-74.