Categories

Volume 5 Issue 6 (June, 2017)

Original Articles

ASSESSMENT OF EFFICACY OF MONTELUKAST AND PSEUDOEPEDRINE IN TREATING PATIENTS OF ALLERGIC RHINITIS- A COMPARATIVE STUDY
Deepika Aggarwal, Isha Aggarwal, Manish Garg

Background: Allergic rhinitis is the most common form of allergic disease, estimated to affect up to 20% of the population worldwide. The current study was planned to assess the efficacy of Montelukast and Pseudoepedrine in treating patients of allergic rhinitis. Material and methods: The study was conducted in the department of General Medicine of the medical institution. For the study, selection of 50 healthy individuals between age group of 18-45 years was done. Patients were randomly grouped into 2 groups, with 25 subjects in each group. Group 1 was prescribed 10 mg of montelukast sodium daily once daily in the morning for 2 weeks. Group 2 was prescribed 240 mg of sustained-release pseudoephedrine hydrochloride once daily in the morning for 2 weeks. Patients were recalled after 2 weeks and variables were noted again. The records kept by the patients were collected on their second visit. Results: The mean age of patients in Group Montelukast Sodium was 30.8 + 8.9 years and in Group Pseudoephedrine hydrochloride was 32.12 + 10.1 years. Male/Female ratio in Group Montelukast Sodium was 14/11 and in Group Pseudoephedrine hydrochloride was 12/13. The mean wheal size in Group Montelukast Sodium and in Group Pseudoephedrine hydrochloride was 12.2 + 1.9 mm and 11.6 + 2.3 mm respectively. We observed significant reduction in total symptom score from day zero to 14th day in pseudoephedrine group (p<0.05). In Montelukast group, we observed significant reduction in total symptom score on all the days as compared to score on day zero except for day 1. Conclusion: Our study shows equivalence in the control of seasonal allergic rhinitis of montelukast and pseudoephedrine administered once daily. In addition to efficacy in the control of nasal symptoms pseudoephedrine was found to be more effective on 1st and 3rd day.
Keywords: Allergy, Montelukast, Pseudoepedrine

 
Html View | Download PDF | Current Issue