Objectives: The purpose of this study was to evaluate the effect of PSA block injection technique with infiltration technique regarding local anesthesia for surgical extraction of maxillary third molar. Methodology: A prospective single-blind randomized controlled trial was designed to study the severity of pain during injection and after surgical extraction of the bilaterally and symmetrically similar upper third molar in a total of 50 patients, in addition to evaluating the need to repeat the injection. Results: Even though the mean pain score for all studied patients in PSA side was lower than the average pain score in infiltration technique, repeated statistical measures confirmed that no significant pain diminution occurred in the two techniques. Conclusion: Both methods have the same statistic equivalence for the surgical extraction of maxillary third molars with the significant advantages of PSA nerve block technique over infiltration technique that least number of necessary injections but at the same time the risk of a potential complication like hematoma also must be considered.
Keywords: Nerve Block, PSA, Third molar.