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Volume 4 Issue 5 (September - October, 2016)

Original Articles

ASSESSMENT OF COST-EFFECTIVENESS AND RECOVERY PROFILE BETWEEN PROPOFOL AND SEVOFLURANE IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY- A COMPARATIVE STUDY
Vivek Maratha, Sandeep Kumar, Archana Dhamija, Jagjeet Manchanda

Background: Regaining of the consciousness as soon as possible along with negligible post-surgical sickness is one of the primary goals of anesthesia administration in short to moderate duration surgeries. In shorter surgeries, propofol has achieved the place of preferred intravenous anaesthetic agent because of its certain kinetic properties which need quicker and complication free recoveries. Another anaesthetic agent with relatively low blood-gas partition coefficient causes faster induction and the emergence with stable hemodynamic is Sevoflurane. Hence, we comparatively evaluated the cost-effectiveness and recovery profile between propofol and sevoflurane in patients undergoing laparoscopic cholecystectomy. Materials & Methods: A total of 180 patients who underwent laparoscopic cholecystectomy from June 2013 to July 2015 were included for the present study. All the patients were randomly divided into three study groups; Group A included patients who received propofol for both maintaining and inducing anaesthesia, Group B included patients who received propofol and sevoflurane for inducing an maintaining general anaesthesia respectively and Group C included patients who received sevoflurane for both maintaining and inducing general anaesthesia. Calculation of the cost of medicines, time duration of anaesthesia and time duration till returning of verbal and hemodynamic responses were noted and evaluated. All the results were analyzed by SPSS software.  Results: Mean age of the patients in group A, B and C were 45.4 years, 41.52 years and 43.85 years respectively. Mean weight of the patients in the different groups was 54.2 kg, 54.7 kg and 56.45 kg respectively. Mean heart rate of the patients at the baseline was highest in the group A patients while in group B patients, it was lowest. Although alteration was seen in between all the study groups, no statistically significant correlation was obtained while comparing the baseline intra-operative parameters in between the various groups. Statistically significant results were obtained while comparing almost all the parameters in between the different groups. Non significant correlation was observed while comparing the side-effects in patients within different groups. Conclusion: In terms of cost-effectiveness, sevoflurane appears to be a better anaesthetic agent.
Key Words: Anaesthesia, Propofol, Sevoflurane

 
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