Journal of AdvancedMedical and Dental Sciences Research

Introduction-Trigeminal neuralgia (TN) is a disease characterized by of unilateral, paroxysmal, stabbing facial pain, originating from the trigeminal nerve. The Pain in Trigeminal neuralgia is characterized as sharp, intense and lancinating in nature. The gold standard drug in terms of efficacy in management of Trigeminal Neuralgisa is still Carbamazepine. Other drugs used for treatment of Trigeminal neuralgia (TN). such as gabapentin, oxcarbazepine, baclofen, lamotrigine, levetiracetam,valproate and botulinum toxin A injection. Objective- To compare the Clinical efficacy of Carbamazepine and Gabapentin in the management of Trigeminal Neuralgia. Materials and Methods- A total of 52 patients with a mean age of 52.78 years included in the study were randomly divided into two groups A and B and were given the tablets of carbamazepine in the dose range of 400mg to 1200 mg and gabapentin in the dose range of 600mg to 1800mg and recalled after 5th day, 15th day, 1 month and 3 month period to evaluate the response to the drugs. The collected data was subjected to statistical analysis. Results- There is significance difference in the response rate of carbamazepine(p>0.05) as therapeutic drug for trigeminal neuralgia. While there is significance difference in the response rate of gabapentin (p>0.05) as therapeutic drugs for trigeminal neuralgia .After three months there is significant difference in response of two drugs studies (P>0.05) .In short duration of management of trigeminal neuralgia both drugs showing significant difference in response however gabapentin shows less side effect as compared to carbapamazipine. However in long term duration(upto 3 month) carbazapine showing significant response as compared to gabapentin.(P<0.004). Conclusion- So,it has been concluded in our that carbamazine is potent drug for trigeminal neuralgia in long term management as compared to gapapentin, however gabapetine is suitable drug for short duration with fewer side effect.